tag:blogger.com,1999:blog-2056279893985574641.post3793435537787429994..comments2023-04-01T12:46:57.529-04:00Comments on Dave' Blog: Inositol Phosphates and Insulin SignalingAnonymoushttp://www.blogger.com/profile/12291507118158076247noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-2056279893985574641.post-27461720339627992482011-01-27T21:56:35.484-05:002011-01-27T21:56:35.484-05:00I was not familiar with the myristoylated Akt tran...I was not familiar with the myristoylated Akt transgenic heart study you quote but that seems very interesting, thanks for pointing that out. My interpretation here was that when Akt is constitutively activated (as in with this transgenic) the basal levels of glucose uptake/glygocen synthesis will be similar to the activated state. They show this pretty clearly in that paper. Its interesting as you and the authors point out that, insulin seems to have less of an effect in this transgenic. This for sure could indicate a negative feedback look in which Akt when activated, is able to feed back to reduce insulin signaling. Classically this could be the Akt-TSC-mTORC1-S6K-IRS loop, but according to the work i describe in my other post (see <a href="http://dave-bridges.blogspot.com/2011/01/irs-serine-phosphorylation-and-insulin.html" rel="nofollow">here</a>) that may not be the answer either. That being said, I would guess that most (maybe all) protein signalling cascades have some sort of negative feedback to limit activation, so if you mimicked activation (like with this transgenic), you would see that feedback very clearly. Thanks for commenting!Anonymoushttps://www.blogger.com/profile/12291507118158076247noreply@blogger.comtag:blogger.com,1999:blog-2056279893985574641.post-11237229985913589442011-01-27T03:12:56.342-05:002011-01-27T03:12:56.342-05:00Nice blog. Congratulations.
I have a small "p...Nice blog. Congratulations.<br />I have a small "paradox": I am troubled by the quote "increased insulin signaling through the Akt pathway leads to increased glucose disposal" ... However, data and research in heart of transgenic mice demonstrate that chronic Akt activation increases basal glucose uptake and glycogen deposition while inhibiting the response to insulin (http://www.ncbi.nlm.nih.gov/pubmed/16352665). Just curious to know the effect of chocolate on akt ...;-)(http://myresipe.blogspot.com/2011/01/chocolate-day-after.html)Kukuhttps://www.blogger.com/profile/00236493931987080317noreply@blogger.com